Young obese patients may benefit from GnRH-a long protocol contributing to higher implantation rate and live birth rate of fresh IVF-ET cycles

IntroductionObesity has detrimental influences on women reproductive health. There is little experience in optimizing controlled ovarian hyperstimulation (COH) protocols to treat Chinese obese patients who are undergoing vitro fertilization and embryo transfer (IVF-ET) therapy.MethodsThe clinical outcome differences were retrospectively analyzed among received gonadotrophin-releasing hormone agonist (GnRH-a), GnRH antagonist (GnRH-ant), micro dose GnRH-a (mGnRH-a) long protocol IVF-ET cycle at Chengdu Jinjiang Hospital for Women's Children's Health from January 2014 December 2019.ResultsThe transplantation rate of the group (59.1%) was higher than that GnRH-ant (25.9%) mGnRH-a (36.7%) groups. The total live birth (46.2%) (40.3%). number frozen embryos other groups (P < 0.05). After adjusting confounding factors, logistic regression analysis showed had probabilities biochemical pregnancy, group. Gn three Whether single or twin, there similar neonatal outcomes four including premature rate, Apgar score, newborn weight, length.ConclusionFor young IVF-ET, COH gives better pregnancy outcomes.